The Future of Cardiovascular Diagnosis, Management and Prognosis
Functional haemodynamic and physiology of the circulatory system is a complex aspect of the human body that is important to diagnosis and treatment. It is understood that functional correction is possible. The gap is in the measuring and understanding of the complex physiological interactions of health & disease. Till date, much emphasis has been laid on structure rather than function, but by shifting the focus, new heights are now scaled in medical and biological signal processing by enabling to map the functions of the organs in the body. Haemoseis applies this technology for cardiovascular diagnosis and management. The procedure is referred to as a 3-Dimensional Vasculography scan.
The breakthrough device, Haemoseis 256 employs advanced patented technologies, Trans-Aortic Signal wave Modulation (TASWM) and Flow Turbulence Accelometry (FTA).The first application of TASWM and FTA, modelling and real time space simulation is in the mapping of the cardiovascular system and understand the tremors deep inside the chest cavity.
3-Dimensional Vasculography, invented and developed by the scientists and engineers at the Centre for Advanced Research and Development (CARD), the research wing of Organisation De Scalene, is simple to use, non-invasive, safe and affordable. Haemoseis 3D Vasculography produces a complete cardiovascular physiological profile.
HAEMOSEIS 256 R – A SNAPSHOT:
Procedure to be conducted by technicians and can be interpreted by Doctors after 6 days training.
Dynamic and continuous real-time monitoring enables early detection of functional changes and realistic detection of coronary artery disease by measuring myocardial blood flow.
Measures, evaluates and computes more than sixty vital applied physiological parameters(comprising beat to beat pressure, volume and time changes) in three to four minutes.
3-D Vasculography TM
3-Dimensional Vasculography produces a complete cardiovascular physiological
profile of the patient consisting of over Sixty functional parameters that directly aid in perfecting diagnosis and treatment.
Physiological Parameters of Human Cardiovascular System obtained after 3-D Vasculography Scan
1-Stroke Volume mL
2-Stroke Index mL/m3
3-Cardiac Output L/min
4-Systemic Vascular Resistance dyne.sec.cm2
5-Mean Arterial Blood Pressure mmHg
6-End Systolic Volume Beat to Beat
7-End Diastolic Volume Beat to Beat
8-Global Myocardial Blood Flow mL/min/100gm
9-Regional Myocardial Blood Flow mL/min/100gm
10-Total Coronary Resistance dyne. sec. cm2
11-Mean Coronary Perfusion Pressure mmHg
12-Systolic and diastolic timings milliseconds
13-Pulmonary Air Retention %
14-Pulmonary Fluid Retention %
15-Pulmonary Capillary Pressure mmHg
16-Pulmonary Vascular Resistance dyne.sec.cm2
17-Renal Glomerular Filtration Rate (GFR) mL/min
18-Urine output mL/min
Functional Parameters of Human Cardiovascular System Obtained after 3-D Vasculography Scan
Left Ventricular ejection fraction LVEF beat to beat
Left Ventricle Regurgitant Fraction
Left Cardiac Work
Maximal Oxygen Consumption
Myocardial Oxygen Demand, Supply & Reserve
Coronary Flow Reserve
Global Myocardial Flow Deficiency Index
Collateral Flow Index
Global Cardiac Efficiency
Thrombus Formation Factor
Total Myocardial Burden
Pliability of mitral and aortic valve
Body Fat Mass Estimate Kgs
Basal Metabolic Rate Kcal/hr/m3
+ The only way to follow neonates, where invasive techniques are impossible.
+ Reliable detection of coronary artery disease and its severity.
+ Understanding underlying causes of chest pain in the absence of CAD
+Forecast signal of Myocardial Ischemia, prior to the development of angina.
+Early detection of CAD in asymptomatic subjects
+Determination of actual working point of the heart and establishes working capacity in post-infarction recovery
+Measurement of iontrop effects
+Establishing ANS activity in patients with diabetic neuropathy
+Establishing arrhythmogenic focus of EAD and DAD in CAD and myocardial diseases
+Establish Proneness to sudden cardiac death syndrome (SCDS).
+Measurement of arterial elasticity and thus the endothelial function and progression of atherosclerosis process in diabetes and hypertension.
+Measurement of ventricular elasticity and diastolic stretch in hypertrophy analysis
+In Anaesthesia-during general narcosis and regional techniques
+Pre-Operative assessment of cardiopulmonary fitness
+In critical care medicine-for monitoring vital functions non-invasively and understand drug action.
+ Optimising AV delay in dual chamber and pace makers..
+ Estimation of GFR,renal fraction and Urine output
+ Establishment of fluid overload during dialysis, plasmapheresis
+Early detection of pulmonary oedema, before the development of clinical symptoms
+Early detection of COPD,its progression and effect of treatment
+Aids in the decision making while choosing the line of management
+Follow up of CABG and PTCA patients.
+Follow up of functional progress during management
+Establishment of functional effectiveness of drugs and medicines
+Establishment of pliability of mitral and aortic valves in valvular patients
+Can be used effectively before, during and after procedures like External Counter Pulsation(ECP) or Intra-Aortic Balloon Pump(IABP),where measurement of coronary perfusion pressure, coronary blood flow, valvular pliability is important
+As a real time teaching aid in functional and applied physiology at a graduate and undergraduate level in medical and nursing schools.
Accuracy and Outcome:
Twenty Years of research and advancements in computing techniques, higher speeds of processing and advancements in mathematical tools have made measurements accurate. Though there are no ‘Gold Standards’ for measuring blood volumes and myocardial blood flow, studies conducted establish adequate cross correlation with the methodologies that indirectly point out to the net effect of physiological changes.
Haemoseis 256 uses algorithm derived from well-known physical laws that are also used in measuring fluid flow and behaviour in many areas of Science and Technology.
A blinded study was conducted in India with 278 patients and the results were published in IEEE CBMS 2001, 26 & 27, July 01, National Institute of Health, Bethesda, Maryland, as a part of the medical devices Regional Blood Flow Reduction to Culprit Vessel Correlation
Primary Presence of CAD (%)
Anterioseptal Region( Correlating with LAD)
Inferioseptal Region(Correlating with RCA)
Lateral Region(Correlating with LCX)
Source; IEEE CBMS-2001.26-27 July 2001,
National Institute of Health, Bethesda, Maryland, USA.